The most notable place in the Athkatla Docks is the Shadow Thieves Guild, the main base for the Shadow Thieves. In chapter 3 in the Shadows of Amn, there is a guild war going on between the Shadow Thieves who are led by Aran Linvail, and the Vampires from the Athkatla Graveyard who are led by Bodhi. The player must side with one of these belligerents and defeat the other's leader. Every night there are ambushes going on in the streets and the player would try to kill the opponent of the side they are on.
Two returning Tales of the Sword Coast characters can be found in the docks; Xzar and Edwin. Xzar wants the player character to help him free Montaron from the Harpers, though he cannot be recruited. Edwin can be found in Mae'Var's Guild, and unlike Xzar he can be recruited.